Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp171 | Obesity (1) | ECE2019

A new generation somatostatin-dopamine chimeric analogue exerts potent antitumoral actions on primary pituitary neuroendocrine tumor cells

Alors-Perez Emilia , Vazquez-Borrego Mari C , L-Lopez Fernando , Galvez-Moreno Maria A , Fuentes-Fayos Antonio C , Venegas-Moreno Eva , Herrera-Martinez Aura D , Blanco-Acevedo Cristobal , Solivera Juan , Landsman Tanya , D Gahete Manuel , Soto-Moreno Alfonso , Culler Michael D , Castano Justo P , Luque Raul M

Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all intracranial tumors and comprise a varied type of neoplasms that, despite being rarely metastatic, can cause severe comorbidities and increased mortality related to the mass effects and hormonal hypersecretion. The high expression levels of somatostatin and dopamine receptors in these tumors has led to the use of somatostatin analogues (SSAs) and dopamine agonists (DAs) as pharmacological treatments....